Host–microbe interactions and the enteric nervous system: a new connection?
نویسندگان
چکیده
منابع مشابه
The enteric nervous system.
T HE enteric nervous system is a collection of neu-rons in the gastrointestinal tract 1 that constitutes the " brain of the gut " and can function independently of the central nervous system. 2 This system controls the motility, 3,4 exocrine and endocrine secretions, 5 and microcirculation 6 of the gastrointestinal tract; it is also involved in regulating immune and inflammatory processes. 7 In...
متن کاملDietary Glutamate: Interactions With the Enteric Nervous System
BACKGROUND/AIMS Digestion of dietary protein elevates intraluminal concentrations of glutamate in the small intestine, some of which gain access to the enteric nervous system (ENS). Glutamate, in the central nervous system (CNS), is an excitatory neurotransmitter. A dogma that glutamatergic neurophysiology in the ENS recapitulates CNS glutamatergic function persists. We reassessed the premise t...
متن کاملImaging neuron-glia interactions in the enteric nervous system
The enteric nervous system (ENS) is a network of neurons and glia within the wall of the gastrointestinal tract that is able to control many aspects of digestive function independently from the central nervous system. Enteric glial cells share several features with astrocytes and are closely associated with enteric neurons and their processes both within enteric ganglia, and along interconnecti...
متن کاملThe human enteric nervous system.
Decades of work in animal models have demonstrated that the enteric nervous system (ENS) plays a key role in controlling gut functions. Recent advances made it possible to extend such studies to the ENS of man in health and even in disease. Such studies have already provided new insights into the pathophysiology of inflammatory and possibly functional bowel diseases. Studies on human ENS reveal...
متن کاملThe enteric nervous system: a second brain.
Once dismissed as a simple collection of relay ganglia, the enteric nervous system is now recognized as a complex, integrative brain in its own right. Although we still are unable to relate complex behaviors such as gut motility and secretion to the activity of individual neurons, work in that area is proceeding briskly--and will lead to rapid advances in the management of functional bowel dise...
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ژورنال
عنوان ژورنال: Nature Reviews Gastroenterology & Hepatology
سال: 2015
ISSN: 1759-5045,1759-5053
DOI: 10.1038/nrgastro.2015.69